Carbenoxolone and incorporation of (3H) glucosamine into gastric mucosa.

The effect of carbenoxolone on incorporation of the labelled sugar, (3H) glucosamine, into rat gastric mucosa was examined. Rats were treated with either 25 mg/kg, or 50 mg/kg or 75 mg/kg carbenoxolone for 10 days. The rats were then killed and the uptake of (3H) glucosamine by gastric mucosal scrapings measured. There was no statistically significant difference in uptake between treated and untreated scrapings. The results do not confirm earlier findings of other investigators which suggested that carbenoxolone promoted gastric ulcer healing by stimulating specific glycosyl transferases to produce a modified mucus.