Fatha Noorul, Ang Li Wei, Goh Kee Tai
Epidemiology and Disease Control Division, Ministry of Health of Singapore, College of Medicine Building, 16 College Road, Singapore 169854, Singapore.
Epidemiology and Disease Control Division, Ministry of Health of Singapore, College of Medicine Building, 16 College Road, Singapore 169854, Singapore.
Int J Infect Dis. 2014 May;22:73-7. doi: 10.1016/j.ijid.2013.10.003. Epub 2013 Nov 21.
To understand the seroepidemiology of varicella zoster virus (VZV) in the Singaporean population, based on a paediatric survey conducted in 2008-2010 and the 2010 National Health Survey. The findings were compared with previous studies carried out in 1989-1990, 1993, 1998, and 2004.
The paediatric survey involved 1200 subjects; residual diagnostic serum samples were collected from Singapore residents aged 1-17 years at two hospitals. The adult survey involved 3293 subjects; residual serum samples were obtained from Singapore residents aged 18-79 years who had participated in the 2010 National Health Survey.
The seroprevalence in children under 5 years of age increased from 4% in 1989/1990 to 11.7% in 1998 and 33.2% in 2008-2010. For children aged 5-14 years, the corresponding seroprevalences were 22.8%, 59.5%, and 58.0%. The seroprevalence in children aged 5-14 years in 2008-2010 was not significantly different from that in 1998 (p=0.721). Among Singapore adults over 25 years of age, the seroprevalence remained consistently high at around 88% from 1998/1990 to 2010.
Nearly two-thirds of pre-school children, 39.5% of primary school children, and 29% of adolescents aged 13-17 years are susceptible to VZV infection. At this level of immunity, it can be expected that outbreaks will continue to occur unless the varicella vaccine is introduced into the national childhood immunization programme.
基于2008 - 2010年开展的一项儿科调查以及2010年国民健康调查，了解新加坡人群中水痘带状疱疹病毒（VZV）的血清流行病学情况。将研究结果与1989 - 1990年、1993年、1998年和2004年之前开展的研究进行比较。
儿科调查涉及1200名受试者；从两家医院1 - 17岁的新加坡居民中收集剩余的诊断血清样本。成人调查涉及3293名受试者；从参与2010年国民健康调查的18 - 79岁新加坡居民中获取剩余血清样本。
5岁以下儿童的血清阳性率从1989/1990年的4%增至1998年的11.7%以及2008 - 2010年的33.2%。对于5 - 14岁儿童，相应的血清阳性率分别为22.8%、59.5%和58.0%。2008 - 2010年5 - 14岁儿童的血清阳性率与1998年相比无显著差异（p = 0.721）。在25岁以上的新加坡成年人中，血清阳性率从1998/1990年至2010年一直保持在约88%的较高水平。
近三分之二的学龄前儿童、39.5%的小学生以及29%的13 - 17岁青少年易感染VZV。在这种免疫水平下，可以预期除非将水痘疫苗纳入国家儿童免疫规划，否则水痘疫情将继续发生。
