Division of Microbiology and Infectious Diseases, Department of Pathology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan.
Department of Microbiology, Faculty of Bio-Science, Nagahama Institute of Bio-Science and Technology, 1266 Tamura-cho, Nagahama, Shiga 526-0829, Japan.
FEBS Lett. 2014 Jan 3;588(1):28-34. doi: 10.1016/j.febslet.2013.11.015. Epub 2013 Nov 20.
Paramyxovirus C protein targets the host interferon (IFN) system for virus immune evasion. To identify its unknown anti-IFN activity, we examined the effect of Sendai virus C protein on activation of the IFN-α promoter via various signaling pathways. This study uncovers a novel ability of C protein to block Toll-like receptor (TLR) 7- and TLR9-dependent IFN-α induction, which is specific to plasmacytoid dendritic cells. C protein interacts with a serine/threonine kinase IKKα and inhibits phosphorylation of IRF7. This anti-IFN activity of C protein is shared across genera of the Paramyxovirinae, and thus appears to play an important role in paramyxovirus immune evasion.
副粘病毒 C 蛋白靶向宿主干扰素（IFN）系统以逃避病毒免疫。为了确定其未知的抗 IFN 活性，我们研究了仙台病毒 C 蛋白对通过各种信号通路激活 IFN-α 启动子的影响。这项研究揭示了 C 蛋白的一种新能力，即阻断 Toll 样受体（TLR）7 和 TLR9 依赖性 IFN-α诱导，这是浆细胞样树突状细胞特有的。C 蛋白与丝氨酸/苏氨酸激酶 IKKα 相互作用并抑制 IRF7 的磷酸化。这种 C 蛋白的抗 IFN 活性在副粘病毒目中的各个属中是共有的，因此似乎在副粘病毒免疫逃避中起着重要作用。
