Desensitization of iloprost responsiveness in human platelets follows prolonged exposure to iloprost in vitro.
作者信息
Alt U, Leigh P J, Wilkins A J, Morris P K, MacDermot J
出版信息
Br J Clin Pharmacol. 1986 Jul;22(1):118-9.
Abstract
摘要
相似文献
1
Desensitization of iloprost responsiveness in human platelets follows prolonged exposure to iloprost in vitro.在体外长时间暴露于伊洛前列素后，人血小板对伊洛前列素的反应性会降低。
Br J Clin Pharmacol. 1986 Jul;22(1):118-9.
2
Heterologous desensitization of platelet adenosine (A2) responses by iloprost.依洛前列素对血小板腺苷（A2）反应的异源脱敏作用。
Adv Prostaglandin Thromboxane Leukot Res. 1987;17A:479-81.
3
Desensitization of prostacyclin responsiveness in platelets. Apparent differences in the mechanism in vitro or in vivo.血小板中前列环素反应性的脱敏。体外或体内机制的明显差异。
Biochem Pharmacol. 1986 Aug 15;35(16):2645-9. doi: 10.1016/0006-2952(86)90169-3.
4
Effect of iloprost on in vivo and in vitro platelet function in patients with peripheral vascular disease (PVD).伊洛前列素对外周血管疾病（PVD）患者体内和体外血小板功能的影响。
Adv Prostaglandin Thromboxane Leukot Res. 1987;17A:450-4.
5
Effects of PGD2, PGE1, and PGI2-analogues on PGDF-release and aggregation of human gelfiltered platelets.
Prog Clin Biol Res. 1989;301:365-9.
6
Iloprost (ZK36374), a stable analogue of prostacyclin, preserves platelets during simulated extracorporeal circulation.依洛前列素（ZK36374），一种前列环素的稳定类似物，在模拟体外循环过程中可保护血小板。
J Thorac Cardiovasc Surg. 1985 Jun;89(6):926-33.
7
Mode of action of PGI2 and of its stable derivative iloprost on platelets and leukocytes.前列环素（PGI2）及其稳定衍生物伊洛前列素对血小板和白细胞的作用机制。
Thromb Res Suppl. 1990;11:33-42. doi: 10.1016/0049-3848(90)90389-t.
8
Effects of PGI2 analog iloprost on myocardial infarct size, regional myocardial blood flow, and platelet function in rabbits with coronary artery occlusion followed by reperfusion.前列环素（PGI2）类似物伊洛前列素对冠状动脉闭塞再灌注家兔心肌梗死面积、局部心肌血流及血小板功能的影响。
Adv Prostaglandin Thromboxane Leukot Res. 1987;17A:377-80.
9
10
Use of Iloprost for leukocyte depletion of platelet concentrates by filtration.伊洛前列素在通过过滤去除血小板浓缩物中白细胞方面的应用。
Vox Sang. 1989;56(4):291-2. doi: 10.1111/j.1423-0410.1989.tb02046.x.
引用本文的文献
1
Acute Respiratory Distress Syndrome and the Use of Inhaled Pulmonary Vasodilators in the COVID-19 Era: A Narrative Review.急性呼吸窘迫综合征与COVID-19时代吸入性肺血管扩张剂的应用：一篇叙述性综述
Life (Basel). 2022 Nov 2;12(11):1766. doi: 10.3390/life12111766.
2
Internalization and down-regulation of the prostacyclin receptor in human platelets.前列环素受体在人血小板中的内化与下调
Biochem J. 1997 Jul 1;325 ( Pt 1)(Pt 1):71-7. doi: 10.1042/bj3250071.
3
Iloprost antagonizes the increase in internal calcium concentration induced by alpha-thrombin in human platelets: a study of desensitization.
Cardiovasc Drugs Ther. 1995 Dec;9(6):773-7. doi: 10.1007/BF00879870.
4
Prostacyclin-dependent cyclic AMP formation in endothelial cells.内皮细胞中前列环素依赖性环磷酸腺苷的形成。
Naunyn Schmiedebergs Arch Pharmacol. 1993 Jan;347(1):101-4. doi: 10.1007/BF00168779.
5
The effect of iloprost on the ADP-ribosylation of Gs alpha (the alpha-subunit of Gs).伊洛前列素对Gsα（Gs的α亚基）ADP核糖基化的影响。
Biochem J. 1989 Aug 1;261(3):841-5. doi: 10.1042/bj2610841.
6
Iloprost-induced translocation of a 23-kDa protein that is recognized by a Gs alpha antiserum.伊洛前列素诱导一种被Gsα抗血清识别的23 kDa蛋白发生易位。
Proc Natl Acad Sci U S A. 1989 Feb;86(3):868-70. doi: 10.1073/pnas.86.3.868.
7
Prostacyclin analogues reduce ADP-ribosylation of the alpha-subunit of the regulatory Gs-protein and diminish adenosine (A2) responsiveness of platelets.前列环素类似物可减少调节性Gs蛋白α亚基的ADP核糖基化，并降低血小板对腺苷（A2）的反应性。
Br J Pharmacol. 1987 Mar;90(3):501-10. doi: 10.1111/j.1476-5381.1987.tb11199.x.
8
Acute reduction of TxA2 platelet binding sites after in vivo administration of a TxA2 receptor inhibitor.体内给予血栓素A2（TxA2）受体抑制剂后，TxA2血小板结合位点的急性减少。
Br J Clin Pharmacol. 1991 Apr;31(4):439-43. doi: 10.1111/j.1365-2125.1991.tb05560.x.
9
Iloprost. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in peripheral vascular disease, myocardial ischaemia and extracorporeal circulation procedures.伊洛前列素。对其药效学和药代动力学特性以及在周围血管疾病、心肌缺血和体外循环手术中的治疗潜力的综述。
Drugs. 1992 Jun;43(6):889-924. doi: 10.2165/00003495-199243060-00008.
本文引用的文献
1
Decreased sensitivity of human platelets to PGI2 during long-term intraarterial prostacyclin infusion in patients with peripheral vascular disease--a rebound phenomenon?外周血管疾病患者长期动脉内输注前列环素期间人血小板对前列环素的敏感性降低——一种反弹现象？
Prostaglandins. 1981 Jan;21(1):49-51. doi: 10.1016/0090-6980(81)90195-7.
2
Desensitization of prostacyclin responsiveness in a neuronal hybrid cell line: selective loss of high affinity receptors.神经元杂交细胞系中前列环素反应性的脱敏：高亲和力受体的选择性丧失。
Br J Pharmacol. 1985 May;85(1):237-47. doi: 10.1111/j.1476-5381.1985.tb08852.x.
3
Evidence for distinct prostaglandin I2 and D2 receptors in human platelets.人类血小板中存在不同前列腺素I2和D2受体的证据。
J Pharmacol Exp Ther. 1979 Jul;210(1):134-40.
Zotero 插件