Sinzinger H, Silberbauer K, Horsch A K, Gall A
Prostaglandins. 1981 Jan;21(1):49-51. doi: 10.1016/0090-6980(81)90195-7.
During successful treatment of peripheral vascular disease with synthetic prostacyclin no alteration in platelet function was reported (1). In 8 patients infused with synthetic prostacyclin continuously for 7 days intraarterially, the platelet function was monitored. Special attention was drawn to the platelet sensitivity in vitro for PGI2, which is discussed as an important factor maintaining the hemostatic balance. In all the patients with peripheral vascular disease between 24 and 48 hours after the beginning of the infusion a sudden decrease in platelet sensitivity accompanied by an increase in platelet count could be seen. These dramatic alterations representing probably a rebound phenomenon occurring during long-term PGI2-treatment might be an explanation for a non-beneficial effect of the treatment and in some cases a limiting factor for the continuation of the infusion itself. It is not clear, if this rebound phenomenon is due to a stimulation of an endogenous inhibitor, lowering the synthesis of a naturally occurring substance acting against this inhibitor or tachyphylaxia.
在用合成前列环素成功治疗外周血管疾病的过程中，未报告血小板功能有改变（1）。对8例连续7天经动脉输注合成前列环素的患者的血小板功能进行了监测。特别关注了血小板在体外对前列环素（PGI2）的敏感性，前列环素被认为是维持止血平衡的一个重要因素。在所有外周血管疾病患者中，输注开始后24至48小时内，可见血小板敏感性突然下降，同时血小板计数增加。这些显著变化可能代表长期PGI2治疗期间出现的一种反跳现象，这可能是治疗无有益效果的一个解释，在某些情况下也是限制输注继续进行的一个因素。目前尚不清楚这种反跳现象是由于内源性抑制剂的刺激、降低了对抗该抑制剂的天然物质的合成，还是由于快速耐受性。
