与青少年抑郁和青春期发育相关的对同伴拒绝的神经反应增强。
Increased neural response to peer rejection associated with adolescent depression and pubertal development.
作者信息
Silk Jennifer S, Siegle Greg J, Lee Kyung Hwa, Nelson Eric E, Stroud Laura R, Dahl Ronald E
机构信息
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA, Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20895, USA, Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI 02903, USA, and School of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA, Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20895, USA, Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI 02903, USA, and School of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA, Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20895, USA, Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI 02903, USA, and School of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA, Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20895, USA, Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI 02903, USA, and School of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA.
出版信息
Soc Cogn Affect Neurosci. 2014 Nov;9(11):1798-807. doi: 10.1093/scan/nst175. Epub 2013 Nov 21.
Sensitivity to social evaluation has been proposed as a potential marker or risk factor for depression, and has also been theorized to increase with pubertal maturation. This study utilized an ecologically valid paradigm to test the hypothesis that adolescents with major depressive disorder (MDD) would show altered reactivity to peer rejection and acceptance relative to healthy controls in a network of ventral brain regions implicated in affective processing of social information. A total of 48 adolescents (ages 11-17), including 21 with a current diagnosis of MDD and 27 age- and gender-matched controls, received rigged acceptance and rejection feedback from fictitious peers during a simulated online peer interaction during functional neuroimaging. MDD youth showed increased activation to rejection relative to controls in the bilateral amygdala, subgenual anterior cingulate, left anterior insula and left nucleus accumbens. MDD and healthy youth did not differ in response to acceptance. Youth more advanced in pubertal maturation also showed increased reactivity to rejection in the bilateral amygdala/parahippocampal gyrus and the caudate/subgenual anterior cingulate, and these effects remained significant when controlling for chronological age. Findings suggest that increased reactivity to peer rejection is a normative developmental process associated with pubertal development, but is particularly enhanced among youth with depression.
对社会评价的敏感性已被提出作为抑郁症的一种潜在标志或风险因素，并且从理论上来说，它会随着青春期成熟而增加。本研究采用了一种生态效度较高的范式，以检验以下假设：与健康对照组相比，患有重度抑郁症（MDD）的青少年在涉及社会信息情感处理的腹侧脑区网络中，对同伴拒绝和接纳的反应会有所改变。共有48名青少年（年龄在11 - 17岁之间）参与了研究，其中包括21名目前被诊断为患有MDD的青少年以及27名年龄和性别匹配的对照组青少年。在功能性神经成像期间的模拟在线同伴互动过程中，他们收到了来自虚拟同伴的虚假接纳和拒绝反馈。与对照组相比，患有MDD的青少年在双侧杏仁核、膝下前扣带回、左侧前脑岛和左侧伏隔核中对拒绝的激活增加。患有MDD的青少年和健康青少年在对接纳的反应上没有差异。青春期成熟程度较高的青少年在双侧杏仁核/海马旁回以及尾状核/膝下前扣带回中对拒绝的反应也增加，并且在控制了实际年龄后，这些效应仍然显著。研究结果表明，对同伴拒绝反应性增加是一个与青春期发育相关的正常发育过程，但在患有抑郁症的青少年中尤其增强。
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