Silk Jennifer S, Lee Kyung Hwa, Elliott Rosalind D, Hooley Jill M, Dahl Ronald E, Barber Anita, Siegle Greg J
Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Soc Cogn Affect Neurosci. 2017 May 1;12(5):729-738. doi: 10.1093/scan/nsx014.
Recent research has implicated altered neural response to interpersonal feedback as an important factor in adolescent depression, with existing studies focusing on responses to feedback from virtual peers. We investigated whether depressed adolescents differed from healthy youth in neural response to social evaluative feedback from mothers. During neuroimaging, twenty adolescents in a current episode of major depressive disorder (MDD) and 28 healthy controls listened to previously recorded audio clips of their own mothers' praise, criticism and neutral comments. Whole-brain voxelwise analyses revealed that MDD youth, unlike controls, exhibited increased neural response to critical relative to neutral clips in the parahippocampal gyrus, an area involved in episodic memory encoding and retrieval. Depressed adolescents also showed a blunted response to maternal praise clips relative to neutral clips in the parahippocampal gyrus, as well as areas involved in reward and self-referential processing (i.e. ventromedial prefrontal cortex, precuneus, and thalamus/caudate). Findings suggest that maternal criticism may be more strongly encoded or more strongly activated during memory retrieval related to previous autobiographical instances of negative feedback from mothers in depressed youth compared to healthy youth. Furthermore, depressed adolescents may fail to process the reward value and self-relevance of maternal praise.
最近的研究表明，青少年抑郁症的一个重要因素是对人际反馈的神经反应改变，现有研究主要关注对虚拟同伴反馈的反应。我们调查了抑郁青少年与健康青少年在对母亲的社会评价反馈的神经反应上是否存在差异。在神经成像过程中，20名处于重度抑郁症（MDD）发作期的青少年和28名健康对照者听取了之前录制的他们自己母亲的表扬、批评和中性评论的音频片段。全脑体素分析显示，与对照组不同，MDD青少年在海马旁回（一个参与情景记忆编码和检索的区域）对批评性片段相对于中性片段表现出增强的神经反应。抑郁青少年在海马旁回以及参与奖励和自我参照加工的区域（即腹内侧前额叶皮层、楔前叶和丘脑/尾状核）对母亲表扬片段相对于中性片段的反应也较为迟钝。研究结果表明，与健康青少年相比，在与之前来自母亲的负面反馈的自传式实例相关的记忆检索过程中，母亲的批评在抑郁青少年中可能被更强地编码或更强烈地激活。此外，抑郁青少年可能无法处理母亲表扬的奖励价值和自我相关性。
