Weir Bruce S
Department of Biostatistics, University of Washington, Box 357232, Seattle, WA 98195-7232, USA, Tel.: +1-206-221-7947.
Stat Biosci. 2013 Nov;5(2). doi: 10.1007/s12561-013-9090-0.
The challenges of whole-genome data, when genotypes are available from hundreds of thousands of genetic markers, are explored for four topics in statistical genetics: Hardy-Weinberg testing, estimating linkage disequilibrium from unphased genotypic data, association mapping and characterizing population structure.
当可从数十万遗传标记获得基因型时，针对统计遗传学中的四个主题探讨了全基因组数据的挑战：哈迪-温伯格检验、从不分型的基因型数据估计连锁不平衡、关联作图以及表征群体结构。
