Tsang K Y, Donnelly R P, Galbraith G M, Fudenberg H H
Int J Immunopharmacol. 1986;8(4):437-41. doi: 10.1016/0192-0561(86)90129-3.
The in vitro effects of isoprinosine (ISO) on the production of IL-1 in AIDS patients and normal controls were investigated in this study. IL-1 production from adherent cells was measured by an indirect method using EL-4 cells. Five of eleven AIDS patients had depressed IL-1 production. Various concentrations of ISO were used to treat the adherent cells in vitro and the optimal concentration for stimulating IL-1 production was determined to be 100 micrograms/ml/10(6) cells. IL-1 production was augmented to normal or to near normal levels in four of five AIDS patients. Our results indicate that depressed immunity seen in some AIDS patients may be partly due to the depressed in IL-1 production and also that ISO can act as an immune potentiation in enhancing the production of this lymphokine in vitro.
本研究调查了异丙肌苷（ISO）对艾滋病患者和正常对照者白细胞介素-1（IL-1）产生的体外影响。采用间接方法，利用EL-4细胞测量贴壁细胞产生的IL-1。11名艾滋病患者中有5名IL-1产生降低。使用不同浓度的ISO体外处理贴壁细胞，确定刺激IL-1产生的最佳浓度为100微克/毫升/10⁶个细胞。5名艾滋病患者中有4名的IL-1产生增加至正常或接近正常水平。我们的结果表明，一些艾滋病患者出现的免疫抑制可能部分归因于IL-1产生降低，并且ISO在体外增强这种淋巴因子产生方面可作为一种免疫增强剂。
