Tsang P, Lew F, O'Brien G, Selikoff I J, Bekesi J G
Int J Immunopharmacol. 1985;7(4):511-4. doi: 10.1016/0192-0561(85)90070-0.
Immunomodulative actions of isoprinosine were tested in 100 prodromal homosexual males and 23 patients who have been diagnosed with AIDS. All subjects showed reduced T helper cells although T suppressor cell counts were normal. Proliferative responses, particularly T cell-dependent B cell function, were severely impaired in prodromal and AIDS subjects. Upon co-cultivation of their lymphocytes with isoprinosine, significant upward modulation, and in some cases, normalization, of lymphocyte functions as monitored by PHA- and PWM-induced blastogenesis was achieved in prodromal subjects. Similar degrees of modulation but not normalization of lymphocyte functions were observed in patients with severe symptoms of AIDS.
对100名前驱期同性恋男性和23名已被诊断为艾滋病的患者进行了异丙肌苷免疫调节作用的测试。所有受试者的辅助性T细胞均减少，尽管抑制性T细胞计数正常。在前驱期和艾滋病患者中，增殖反应，尤其是T细胞依赖性B细胞功能严重受损。将他们的淋巴细胞与异丙肌苷共同培养后，前驱期受试者通过PHA和PWM诱导的细胞增殖反应监测到淋巴细胞功能有显著上调，在某些情况下甚至恢复正常。在艾滋病重症患者中观察到淋巴细胞功能有类似程度的调节，但未恢复正常。
