Soria-Céspedes Danny, Canchola Aguilar Guadalupe, Lara-Torres César Octavio, Sánchez-Marle Juan Felipe, Hernández-Peña Roberto Enrique, Ortiz-Hidalgo Carlos
Departamento de Patología, Centro Médico ABC (The American British Cowdray Medical Center), México, D.F.
Gac Med Mex. 2013 Nov-Dec;149(6):673-9.
Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma has been identified as a distinct entity within squamous cell carcinoma of the head and neck. In contrast to carcinomas associated with alcohol and/or tobacco, this subtype occurs at younger age, with frequent absence of classic risk factors, correlation with oral sexual habits, strong predilection for the palatial tonsils and the base of the tongue (lingual tonsils), basaloid or lymphoepithelial differentiation, higher degree of radiosensitivity, and overall better survival. We report two cases of lymph node, metastatic, poorly differentiated squamous cell carcinoma that were positive by immunohistochemistry for p16 with detection of HPV-16 and HPV-45 by PCR.
人乳头瘤病毒（HPV）相关的口咽鳞状细胞癌已被确定为头颈部鳞状细胞癌中的一个独特实体。与酒精和/或烟草相关的癌不同，这种亚型发病年龄较轻，常无典型危险因素，与口交习惯相关，强烈倾向于腭扁桃体和舌根（舌扁桃体），具有基底样或淋巴上皮分化，放射敏感性较高，总体生存率较好。我们报告了两例淋巴结转移性低分化鳞状细胞癌，免疫组化p16呈阳性，通过聚合酶链反应检测到HPV-16和HPV-45。
