Krenger W, Honegger C G, Feurer C, Cammisuli S
J Neurochem. 1986 Oct;47(4):1247-54. doi: 10.1111/j.1471-4159.1986.tb00747.x.
Catecholamine and indoleamine neurotransmitters, together with some of their precursors and metabolites, were determined using HPLC in three brain and two spinal cord regions of Lewis rats with chronic relapsing allergic encephalomyelitis and of control rats injected with complete Freund's adjuvant. Three attacks and two recovery phases were investigated. Changes are found mainly in the spinal cord. In the lumbosacral region both 5-hydroxytryptamine and noradrenaline are reduced during the entire course of the disease, whereas in the craniothoracal region 5-hydroxytryptamine is unchanged and only noradrenaline is reduced during the attacks, returning to normal during the first recovery. The precursors tyrosine and tryptophan are greatly elevated during the first two attacks in both regions. The 5-hydroxytryptamine turnover marker 5-hydroxyindoleacetic acid is increased in the first attack in both regions, then it decreases in the later stages, indicating destruction of nerve fibers. On the fourth and seventh days after inoculation values are generally not significantly different from controls in all regions. The possible correlation of neurochemical results with neurological signs is discussed.
使用高效液相色谱法（HPLC）测定了患有慢性复发性变应性脑脊髓炎的Lewis大鼠以及注射了完全弗氏佐剂的对照大鼠的三个脑区和两个脊髓区中的儿茶酚胺和吲哚胺神经递质，以及它们的一些前体和代谢产物。研究了三次发作和两个恢复阶段。变化主要发生在脊髓中。在腰骶部区域，5-羟色胺和去甲肾上腺素在疾病的整个过程中均减少，而在颅胸部区域，5-羟色胺没有变化，仅在发作期间去甲肾上腺素减少，在首次恢复期间恢复正常。在前两次发作期间，两个区域的前体酪氨酸和色氨酸均大幅升高。5-羟色胺周转标志物5-羟吲哚乙酸在两个区域的首次发作中均增加，然后在后期减少，表明神经纤维受到破坏。接种后第四天和第七天，所有区域的值通常与对照组无显著差异。讨论了神经化学结果与神经学体征之间可能的相关性。
