White S R, Bhatnagar R K, Bardo M T
J Neurochem. 1983 Jun;40(6):1771-3. doi: 10.1111/j.1471-4159.1983.tb08156.x.
Norepinephrine and dopamine concentrations were determined by radioenzymatic assay in discrete gray matter regions of the spinal cords of rats with experimental allergic encephalomyelitis (EAE). Norepinephrine was depleted in most spinal cord regions of EAE rats compared with controls, whereas dopamine depletion in EAE rats was restricted to the cervical dorsal horn. There was a rostrocaudal gradient of norepinephrine reduction in the spinal cords of the EAE rats with most severe depletion in the lumbar region. The results of this experiment confirmed recent anatomical observations that suggested that catecholamine-fluorescent axons and terminals were damaged in spinal cords of rats with EAE.
通过放射酶分析法测定实验性变态反应性脑脊髓炎（EAE）大鼠脊髓离散灰质区域中的去甲肾上腺素和多巴胺浓度。与对照组相比，EAE大鼠的大多数脊髓区域去甲肾上腺素耗竭，而EAE大鼠的多巴胺耗竭仅限于颈背角。EAE大鼠脊髓中去甲肾上腺素减少存在头-尾梯度，腰段区域耗竭最为严重。该实验结果证实了最近的解剖学观察结果，即EAE大鼠脊髓中的儿茶酚胺荧光轴突和终末受到损伤。
