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Detection of early cognitive impairment using AD8 in a young patient with stroke with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy syndrome: a case report.应用 AD8 检测脑常染色体显性动脉病伴皮质下梗死和白质脑病（CADASIL）综合征年轻脑卒中患者的早期认知障碍：病例报告
Am J Alzheimers Dis Other Demen. 2014 Mar;29(2):133-7. doi: 10.1177/1533317513511289. Epub 2013 Nov 24.
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Lacunar infarcts are the main correlate with cognitive dysfunction in CADASIL.腔隙性脑梗死是伴有皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病（CADASIL）中认知功能障碍的主要相关因素。
Stroke. 2007 Mar;38(3):923-8. doi: 10.1161/01.STR.0000257968.24015.bf. Epub 2007 Feb 1.
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Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy resulting in stroke in an 11-year-old male.一名11岁男性患大脑常染色体显性动脉病伴皮质下梗死和白质脑病导致中风
Dev Med Child Neurol. 2009 Sep;51(9):754-7. doi: 10.1111/j.1469-8749.2008.03241.x. Epub 2009 Jan 29.
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[CADASIL syndrome - cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy].[伴有皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病（CADASIL综合征）]
Neurol Neurochir Pol. 2008 Mar-Apr;42(2):123-30.
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Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) associated with a novel C82R mutation in the NOTCH3 gene.伴有NOTCH3基因新型C82R突变的大脑常染色体显性动脉病伴皮质下梗死和白质脑病（CADASIL）
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Renal involvement in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).脑常染色体显性遗传性动脉病伴皮质下梗死和白质脑病（CADASIL）中的肾脏受累情况。
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Comparison of clinical, familial, and MRI features of CADASIL and NOTCH3-negative patients.比较 CADASIL 和 NOTCH3 阴性患者的临床、家族和 MRI 特征。
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[Clinical features in 4 Chinese families with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)].4个患有伴有皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病（CADASIL）的中国家系的临床特征
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Childhood-onset CADASIL: clinical, imaging, and neurocognitive features.儿童期起病的大脑常染色体显性动脉病伴皮质下梗死和白质脑病（CADASIL）：临床、影像学及神经认知特征
J Child Neurol. 2010 May;25(5):623-7. doi: 10.1177/0883073810361382. Epub 2010 Mar 1.
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Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy without anterior temporal pole involvement: a case report.无颞极前部受累的大脑常染色体显性遗传性动脉病伴皮质下梗死和白质脑病：一例报告
J Stroke Cerebrovasc Dis. 2014 Mar;23(3):e241-2. doi: 10.1016/j.jstrokecerebrovasdis.2013.10.013. Epub 2013 Dec 2.

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AD-8 for detection of dementia across a variety of healthcare settings.用于在各种医疗环境中检测痴呆症的AD-8量表。
Cochrane Database Syst Rev. 2019 Mar 4;3(3):CD011121. doi: 10.1002/14651858.CD011121.pub2.

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Cross-cultural Adaptation of the "Functional Activities Questionnaire - FAQ" for use in Brazil.《功能活动问卷 - FAQ》在巴西使用的跨文化适应性研究
Dement Neuropsychol. 2011 Oct-Dec;5(4):322-327. doi: 10.1590/S1980-57642011DN05040010.
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Memory Span Tests.记忆广度测试。
Psychol Clin. 1919 May 15;12(5-9):196-200.
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Montreal Cognitive Assessment and Mini-Mental State Examination performance in patients with mild-to-moderate dementia with Lewy bodies, Alzheimer's disease, and normal participants in Taiwan.台湾地区轻度至中度路易体痴呆、阿尔茨海默病患者和正常参与者的蒙特利尔认知评估和简易精神状态检查表现。
Int Psychogeriatr. 2013 Nov;25(11):1839-48. doi: 10.1017/S1041610213001245. Epub 2013 Aug 7.
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Utility of the AD8 as a self-rating tool for cognitive impairment in an Asian population.AD8 作为一种自评工具在亚洲人群认知障碍中的效用。
Am J Alzheimers Dis Other Demen. 2013 May;28(3):284-8. doi: 10.1177/1533317513481090. Epub 2013 Mar 14.
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White matter dementia.脑白质痴呆。
Ther Adv Neurol Disord. 2012 Sep;5(5):267-77. doi: 10.1177/1756285612454323.
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Practical guidelines for the recognition and diagnosis of dementia.实用的痴呆症识别和诊断指南。
J Am Board Fam Med. 2012 May-Jun;25(3):367-82. doi: 10.3122/jabfm.2012.03.100181.
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The reliability of assigning individuals to cognitive states using the Mini Mental-State Examination: a population-based prospective cohort study.使用简易精神状态检查将个体分配到认知状态的可靠性：一项基于人群的前瞻性队列研究。
BMC Med Res Methodol. 2011 Sep 6;11:127. doi: 10.1186/1471-2288-11-127.
8
Assessing executive abilities following acute stroke with the trail making test and digit span.用连线测试和数字跨度评估急性脑卒中后的执行能力。
Behav Neurol. 2011;24(3):177-85. doi: 10.3233/BEN-2011-0328.
9
Application of AD8 questionnaire to screen very mild dementia in Taiwanese.应用 AD8 问卷筛查台湾地区极轻度痴呆。
Am J Alzheimers Dis Other Demen. 2011 Mar;26(2):134-8. doi: 10.1177/1533317510397330.
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CADASIL.CADASIL.
J Geriatr Psychiatry Neurol. 2010 Dec;23(4):269-76. doi: 10.1177/0891988710383570.

应用 AD8 检测脑常染色体显性动脉病伴皮质下梗死和白质脑病（CADASIL）综合征年轻脑卒中患者的早期认知障碍：病例报告

Detection of early cognitive impairment using AD8 in a young patient with stroke with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy syndrome: a case report.

机构信息

1Department of Physical Medicine and Rehabilitation, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

出版信息

Am J Alzheimers Dis Other Demen. 2014 Mar;29(2):133-7. doi: 10.1177/1533317513511289. Epub 2013 Nov 24.

DOI:10.1177/1533317513511289
PMID:24277909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10852698/
Abstract

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) syndrome is a hereditary disease resulting from NOTCH3 gene mutation. The clinical presentations include migraine, recurrent stroke, and cognitive impairment. The severity of cognitive impairment varies in different stages, and early recognition poses a challenge. A 47-year-old lady presented with chronic migraine and sudden onset of hemiparesis. Magnetic resonance imaging revealed compatible findings of CADASIL, which was confirmed by mutation analysis of NOTCH3 gene. Early cognitive impairment was detected by her score of 3 in Ascertain Dementia 8 (AD8) questionnaire and confirmed by detailed neuropsychological assessments. After 21 months of follow-up, deterioration in her cognition and ability to perform instrumental activities of daily living were significant with a follow-up AD8 score of 7. Ascertain Dementia 8 questionnaire is an easy and valid screening tool for early cognitive impairment in patients with CADASIL syndrome.

摘要

伴皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病（CADASIL）综合征是一种由 NOTCH3 基因突变引起的遗传性疾病。其临床表现包括偏头痛、反复发作性卒中和认知障碍。不同阶段认知障碍的严重程度不同，早期识别具有挑战性。一位 47 岁女性因慢性偏头痛和突发偏瘫就诊。磁共振成像显示符合 CADASIL 的发现，NOTCH3 基因突变分析证实了这一点。AD8 问卷评分 3 分提示早期认知障碍，并通过详细的神经心理学评估得到证实。经过 21 个月的随访，她的认知功能和进行日常工具性活动的能力明显恶化，随访时 AD8 评分为 7。AD8 问卷是一种用于筛查 CADASIL 综合征患者早期认知障碍的简单有效的工具。