轮状病毒腹泻在五岁以下住院儿童中的流行情况。

Prevalence of rotavirus diarrhea among hospitalized under-five children.

机构信息

Department of Pediatrics, Malankara Orthodox Syrian Church Medical College Hospital, Kolenchery, Ernakulam District, Kerala; Department of Microbiology, Christian Medical College, Vellore, India and Division of Translational Research, International Vaccine Institute, Seoul, South Korea. Correspondence to: Dr MA Mathew, Professor, Department of Pediatrics, Malankara Orthodox Syrian Church Medical College Hospital, Kolenchery, Ernakulam District, Kerala 682 311, India.

出版信息

Indian Pediatr. 2014 Jan;51(1):27-31. doi: 10.1007/s13312-014-0329-8. Epub 2013 Sep 5.

DOI:10.1007/s13312-014-0329-8

PMID:24277960

Abstract

OBJECTIVE

To estimate the prevalence of rotavirus diarrhea among hospitalized children less than 5 years of age in Kerala State and to determine the circulating strains of rotavirus in Kerala.

DESIGN

Multicenter, cross-sectional study.

SETTING

Eight representative hospitals in Kunnathunadu Thaluk, Ernakulam district, Kerala.

PARTICIPANTS

Children in the age group under 5 years.

METHODS

Hospitalized children admitted with acute diarrhea were examined and standardized case report form was used to collect demographic, clinical and health outcome. Stool specimens were collected and ELISA testing was done. ELISA rotavirus positive samples were tested by reverse transcription PCR for G and P typing (CMC Vellore).

RESULTS

Among the 1827 children, 648 (35.9%) were positive for rotavirus by the Rotaclone ELISA test. The prevalence of rotavirus diarrhea in infants less than 6 months of age was 24.7%; 6- 11 months 31.9%; 12- 23 months 41.9%; 24- 35 months 46.9%; and 33.3% in 36- 59 months. Rotavirus infections were most common during the dry months from January through May. G1P[8] (49.7%) was the most common strain identified followed by G9P[8] (26.4%), G2P[4] (5.5%), G9P[4] (2.6%) and G12P[6] (1.3%).

CONCLUSIONS

The prevalence of rotavirus diarrhea among hospitalized children less than 5 years is high in Ernakulam district, Kerala State.

摘要

目的

估计喀拉拉邦住院 5 岁以下儿童轮状病毒腹泻的流行率，并确定喀拉拉邦的轮状病毒循环株。

设计

多中心、横断面研究。

地点

喀拉拉邦埃纳库拉姆区库纳图纳德图鲁克的 8 家代表性医院。

参与者

5 岁以下儿童。

方法

检查因急性腹泻住院的儿童，并使用标准化病例报告表收集人口统计学、临床和健康结果。采集粪便标本并进行 ELISA 检测。对 ELISA 轮状病毒阳性样本进行逆转录 PCR 检测 G 和 P 型（CMC Vellore）。

结果

在 1827 名儿童中，648 名（35.9%）通过 Rotaclone ELISA 检测呈轮状病毒阳性。6 个月以下婴儿的轮状病毒腹泻患病率为 24.7%；6-11 个月为 31.9%；12-23 个月为 41.9%；24-35 个月为 46.9%；36-59 个月为 33.3%。轮状病毒感染最常见于 1 月至 5 月的干燥月份。G1P[8]（49.7%）是最常见的识别株，其次是 G9P[8]（26.4%）、G2P[4]（5.5%）、G9P[4]（2.6%）和 G12P[6]（1.3%）。