印度安得拉邦五岁以下因急性肠胃炎入院儿童中轮状病毒的两年流行率。
Two-Year Prevalence of Rotavirus Among Under-Five Children Admitted with Acute Gastroenteritis in Andhra Pradesh, India.
机构信息
Department of Community Medicine, Rangaraya Medical College, Kakinada, Andhra Pradesh, 533001, India.
Department of Pediatrics, Rangaraya Medical College, Kakinada, Andhra Pradesh, India.
出版信息
Indian J Pediatr. 2021 Mar;88(Suppl 1):72-77. doi: 10.1007/s12098-020-03608-1. Epub 2021 Jan 16.
OBJECTIVE
To estimate the burden of rotavirus diarrhea among under-five children admitted with acute gastroenteritis and to identify genotypes of rotavirus among positive rotavirus cases.
METHODS
This is a cross-sectional study conducted from August 2017 to July 2019 in Government General Hospital and 5 private pediatric nursing homes (Padma Children's Hospital, Mother and Child Hospital, Chandamama Children's Hospital, Vennela Hospital) in Kakinada. Children admitted to the pediatric ward with acute gastroenteritis were included in this study. Stool samples were collected from all these children and tested for rotavirus by enzyme-linked immunosorbent assay and the positive samples were genotyped using reverse transcriptase polymerase chain reaction.
RESULTS
Rotavirus diarrhea was seen in 7.4% of children among all diarrhea admissions. The mean age of the rotavirus-positive children was 13.1 ± 10 mo. The most common genotype in 2017 was G3P[8], and that in 2018 and 2019 was the mixed genotype.
CONCLUSION
In this study, mixed genotype was found to be most common.
目的
评估因急性肠胃炎入院的五岁以下儿童中轮状病毒腹泻的负担，并鉴定轮状病毒阳性病例中的病毒基因型。
方法
这是一项 2017 年 8 月至 2019 年 7 月在卡基纳达（Kakinada）政府综合医院和 5 家私立儿科疗养院（Padma 儿童医院、母婴医院、Chandamama 儿童医院、Vennela 医院）进行的横断面研究。该研究纳入了儿科病房因急性肠胃炎入院的所有儿童。收集所有这些儿童的粪便样本，通过酶联免疫吸附试验检测轮状病毒，对阳性样本采用逆转录聚合酶链反应进行基因分型。
结果
所有腹泻住院患儿中，轮状病毒腹泻占 7.4%。轮状病毒阳性患儿的平均年龄为 13.1±10 个月。2017 年最常见的基因型为 G3P[8]，而 2018 年和 2019 年则为混合基因型。
结论
在这项研究中，发现混合基因型最为常见。
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