Department of Biotechnology, University of Malakand (Chackdara), Pakistan ; Department of Biotechnology, School of Life Sciences, Kyunpook National University, Daegu 702-701, Korea.
Toxicol Res. 2011 Sep;27(3):143-7. doi: 10.5487/TR.2011.27.3.143.
Cadmium is considered one of the most toxic, non biodegradable heavy metal for the human and animals. The purpose of the present study was to investigate the changes in biochemical parameters of blood and accumulation of cadmium in various tissue caused by various levels of dietary cadmium chloride (CdCl2) in broiler chicks. CdCl2 was administered through drinking water to broiler chicks. In spectral analysis, CdCl2 treatment caused a significant increase in Glutamate pyruvate transaminase (GPT), creatinine and uric acid levels in all treated groups. Intriguingly, the GPT, creatinine, and uric acid levels were significantly higher at 75 mg/kg as compared to the groups treated with high doses (100, 125 and 150 mg/kg) of CdCl2. Atomic Absorption Spectrophotometer (AAS) was used for the determination of Cd accumulation in kidney, liver and Breast muscles. AAS analysis revealed that Cd accumulation is increased in breast muscles as compared to liver and kidney at higher doses of Cd than 75 mg/kg.
镉被认为是对人类和动物最有毒、最难生物降解的重金属之一。本研究的目的是研究日粮氯化镉（CdCl2）不同水平对肉鸡血液生化参数的变化和各组织中镉的积累。通过饮水给肉鸡喂食 CdCl2。在光谱分析中，CdCl2 处理导致所有处理组的谷氨酸丙酮酸转氨酶（GPT）、肌酐和尿酸水平显著升高。有趣的是，与高剂量（100、125 和 150mg/kg）CdCl2 处理组相比，75mg/kg 剂量组的 GPT、肌酐和尿酸水平显著升高。原子吸收分光光度计（AAS）用于测定肾脏、肝脏和胸肌中的镉积累。AAS 分析表明，与肝脏和肾脏相比，在高于 75mg/kg 的 Cd 剂量下，镉在胸肌中的积累增加。
