Mustari Afrina, Alam Mahabub, Khatun Murshida, Rockybul Alam Md, Alam Miah Mohammad, Haque Chowdhury Emdadul
Department of Physiology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensigh 2202, Bangladesh.
Department of Pathology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensigh 2202, Bangladesh.
Saudi J Biol Sci. 2023 Sep;30(9):103742. doi: 10.1016/j.sjbs.2023.103742. Epub 2023 Jul 20.
Cadmium (Cd) is a pollutant that poses a health risk for humans and animals. Coral fossil (CF) acts as an adsorbent, yet limited knowledge is available on impacts of CF on Cd toxicities. The work was performed to figure out the effects of CF on hematobiochemical details and specific organs in Cd exposed broilers. The experiment was carried out with 45 broilers and were divided into three groups (15 in each). Group A was served as control. The birds in group B received Cd (75 mg /kg b. w.) orally. Whereas group C was orally supplemented with Cd (75 mg /kg b. w.) and CF (1 gm/kg b. w.). The trial was lasted for 30 days. For hematobiochemical analysis, blood samples were drawn, and sera were separated. Liver, kidney and muscle were collected to assess accumulation concentration. Brain, liver and kidney samples were also collected for histopathological study. The results showed that hematological parameters (TEC, Hb, PCV, MCV, MCH, MCHC and DLC) were altered by Cd but restored with CF supplementation. Liver (AST, ALT and ALP) and kidney (total protein and creatinine) biomarkers were increased significantly in Cd treated broilers while decreased significantly after CF supplementation. CF reduced accumulation concentration of Cd in liver, kidney and muscle. Cd intoxicated broilers showed degenerative changes in brain, hyperplastic bile duct and proliferation of renal tubular epithelium with focal degeneration and necrosis; and these were improved after CF supplementation. Therefore, it can be concluded that CF is a potential adsorbent against Cd toxicities.
镉（Cd）是一种对人类和动物健康构成风险的污染物。珊瑚化石（CF）可作为一种吸附剂，但关于CF对镉毒性影响的了解有限。开展这项工作是为了弄清楚CF对镉暴露肉鸡血液生化指标和特定器官的影响。实验用45只肉鸡进行，分为三组（每组15只）。A组作为对照组。B组的鸡口服镉（75毫克/千克体重）。而C组口服补充镉（75毫克/千克体重）和CF（1克/千克体重）。试验持续30天。为进行血液生化分析，采集血样并分离血清。收集肝脏、肾脏和肌肉以评估蓄积浓度。还收集大脑、肝脏和肾脏样本进行组织病理学研究。结果表明，血液学参数（TEC、Hb、PCV、MCV、MCH、MCHC和DLC）因镉而改变，但补充CF后恢复正常。镉处理的肉鸡肝脏（AST、ALT和ALP）和肾脏（总蛋白和肌酐）生物标志物显著升高，而补充CF后显著降低。CF降低了镉在肝脏、肾脏和肌肉中的蓄积浓度。镉中毒的肉鸡大脑出现退行性变化、胆管增生以及肾小管上皮细胞增殖并伴有局灶性变性和坏死；补充CF后这些情况得到改善。因此，可以得出结论，CF是一种对抗镉毒性的潜在吸附剂。
