Schindl R, Würtz J, Hoffmann H
J Cardiovasc Pharmacol. 1986;8 Suppl 4:S99-101. doi: 10.1097/00005344-198608004-00021.
The influence of single oral doses of 200 mg celiprolol, 100 mg atenolol, and 200 mg metoprolol on airway resistance (Raw) FEV1, VC, and MEF 50 was studied in a randomized double-blind crossover trial. Eighteen patients with hypertension and asthma, 14 men and 4 women, aged 43-75 years, took part. Pulmonary function tests were performed in the morning before treatment and 2 and 5 h after each treatment in the whole-body plethysmograph. The use of bronchodilators was not allowed during the 3 days. There was no significant change in airway resistance, FEV1, and MEF 50 after celiprolol and a slight increase of vital capacity at 2 h. After atenolol there was a decrease of FEV1 and MEF 50 at 5 h. Metoprolol caused an increase in resistance at 2 and 5 h and a fall in FEV1, VC, and MEF 50 at 2 and 5 h. Two patients required bronchodilator therapy after metoprolol and were excluded from evaluation. We conclude that celiprolol appears to be a safe drug in the treatment of asthmatic patients.
在一项随机双盲交叉试验中，研究了单次口服200毫克塞利洛尔、100毫克阿替洛尔和200毫克美托洛尔对气道阻力（Raw）、第一秒用力呼气容积（FEV1）、肺活量（VC）和最大呼气中期流速（MEF 50）的影响。18例患有高血压和哮喘的患者参与了研究，其中14名男性和4名女性，年龄在43至75岁之间。在全身体积描记器中，于治疗前的早晨以及每次治疗后的2小时和5小时进行肺功能测试。在3天内不允许使用支气管扩张剂。服用塞利洛尔后气道阻力、FEV1和MEF 50无显著变化，肺活量在2小时时有轻微增加。服用阿替洛尔后，5小时时FEV1和MEF 50下降。美托洛尔在2小时和5小时时导致阻力增加，在2小时和5小时时FEV1、VC和MEF 50下降。两名患者在服用美托洛尔后需要支气管扩张剂治疗，被排除在评估之外。我们得出结论，塞利洛尔似乎是治疗哮喘患者的一种安全药物。
