Bruschi C, Casali L, Cerveri I, Peona V, Zoia M C
Istituto di Tisiologia, University of Pavia, Italy.
Am J Cardiol. 1988 Feb 10;61(5):53C-54C. doi: 10.1016/0002-9149(88)90487-0.
In 10 patients with bronchial asthma but normal ventilatory function, celiprolol, a cardioselective beta-adrenoreceptor antagonist, did not significantly affect forced expiratory volume in 1 second (FEV1) or airways resistance (Raw). In contrast, metoprolol substantially reduced FEV1 and increased Raw. In addition, compared with metoprolol, celiprolol induced a greater recovery of FEV1 and Raw after methacholine-induced bronchoconstriction.
在10例支气管哮喘但通气功能正常的患者中，心脏选择性β-肾上腺素能受体拮抗剂塞利洛尔对一秒用力呼气量（FEV1）或气道阻力（Raw）无显著影响。相比之下，美托洛尔显著降低了FEV1并增加了Raw。此外，与美托洛尔相比，塞利洛尔在乙酰甲胆碱诱发支气管收缩后能使FEV1和Raw有更大程度的恢复。
