Int J Oral Maxillofac Implants. 2013 Nov-Dec;28(6):e451-60. doi: 10.11607/jomi.te25.
Two types of dentition are generated in a human's lifetime: the primary dentition, followed by the permanent dentition. Undoubtedly, teeth are essential for speech and mastication in both dentitions, but it is becoming apparent that dental pulp also plays a role in harboring mesenchymal stem cells (MSCs). To date, three kinds of MSCs derived from dental pulp have been established: permanent tooth, primary tooth, and immature apical papilla. The dental pulp from primary teeth is considered a particularly good source of MSCs; it can be obtained from extracted primary teeth, of which humans have 20. The past decade has seen many reports of dental pulp-derived MSCs, and the field is becoming increasingly popular. The present article describes the characterization of dental pulp-derived MSCs from primary teeth. It also discusses future banking activity of primary teeth, because it is known that dental pulp-derived MSCs have similar potential to those derived from bone marrow. Methods with which to optimize the cryopreservation process should therefore be investigated, because banked dental pulp may provide a great resource in future regenerative medicine.
乳牙和恒牙。毋庸置疑，在这两种牙齿中，牙齿对于言语和咀嚼都非常重要，但目前已经明显发现牙髓中也存在间充质干细胞（MSCs）。迄今为止，已经从牙髓中分离出三种 MSCs：恒牙、乳牙和未成熟根尖乳头。乳牙牙髓被认为是 MSCs 的一个特别好的来源；它可以从已拔出的乳牙中获得，人类有 20 颗乳牙。过去十年中，有许多关于牙髓来源的 MSCs 的报道，该领域越来越受欢迎。本文描述了从乳牙中分离的牙髓来源的 MSCs 的特征。本文还讨论了未来对乳牙的储存活动，因为已知牙髓来源的 MSCs 与骨髓来源的 MSCs 具有相似的潜力。因此，应该研究优化冷冻保存过程的方法，因为储存的牙髓可能在未来的再生医学中提供巨大的资源。
