含血小板反应蛋白基序的解聚素和金属蛋白酶4及5在骨关节炎中的研究进展
[Research progress of a disintegrin and metalloproteinase with thrombospondin motif 4 and 5 in osteoarthritis].
作者信息
Ji Quanbo, Zhang Qiang, Wang Yan
机构信息
Department of Orthopedics, the General Hospital of Chinese PLA, Beijing, 100853, P.R.China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2013 Sep;27(9):1080-4.
OBJECTIVE
To review the progress of a disintegrin and metalloproteinase with thrombospondin motif 4 (ADAMTS-4) and ADAMTS-5 in osteoarthritis.
METHODS
Recent literature about the ADAMTS-4 and -5 in osteoarthritis was analyzed; the structure, function, inhibitors of the ADAMTS-4 and -5, and the relationship between the proteases and osteoarthritis were analyzed and summarized.
RESULTS
ADAMTS-4 and -5 can reduce chondrocyte and extracellular matrix by degrading aggrecan and cartilage oligomeric matrix protein, which induced the pathogenesis of osteoarthritis.
CONCLUSION
ADAMTS-4 and -5 have been demonstrated to play important roles in osteoarthritis. It can better guide treatment and prevention of osteoarthritis to further study related mechanism of ADAMTS-4 and -5, and to promote the establishment of a clinical drug targets.
目的
综述含血小板反应蛋白基序的解聚素和金属蛋白酶4（ADAMTS-4）及ADAMTS-5在骨关节炎中的研究进展。
方法
分析近期有关ADAMTS-4和-5在骨关节炎方面的文献；对ADAMTS-4和-5的结构、功能、抑制剂以及这些蛋白酶与骨关节炎之间的关系进行分析和总结。
结果
ADAMTS-4和-5可通过降解聚集蛋白聚糖和软骨寡聚基质蛋白减少软骨细胞和细胞外基质，从而引发骨关节炎的发病机制。
结论
已证实ADAMTS-4和-5在骨关节炎中起重要作用。进一步研究ADAMTS-4和-5的相关机制，促进临床药物靶点的确立，能够更好地指导骨关节炎的治疗和预防。
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