Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.
J Cell Biochem. 2011 Dec;112(12):3507-14. doi: 10.1002/jcb.23298.
Osteoarthritis (OA) is a progressive disease of the joints characterized by degradation of articular cartilage. Although disease initiation may be multi-factorial, the cartilage destruction appears to be a result of uncontrolled proteolytic extracellular matrix destruction. A major component of the cartilage extracellular matrix is aggrecan, a proteoglycan that imparts compressive resistance to the tissue. Aggrecanase-mediated aggrecan degradation is a significant event in early stage OA. The relative contribution of individual ADAMTS-4 and ADAMTS-5 proteinases to cartilage destruction during OA has not been resolved completely. This review reveals that both ADAMTS-4/ADAMTS-5 are responsible for aggrecan degradation in a human model of OA, and is expected to list down the rational strategies which are being focussed for therapeutic intervention in OA.
骨关节炎（OA）是一种以关节软骨退化为特征的进行性疾病。尽管疾病的发生可能是多因素的，但软骨的破坏似乎是由于细胞外基质的失控性蛋白水解引起的。软骨细胞外基质的主要成分是聚集蛋白聚糖，它赋予组织抗压能力。聚集蛋白聚糖酶介导的聚集蛋白聚糖降解是早期 OA 的一个重要事件。ADAMTS-4 和 ADAMTS-5 蛋白酶在 OA 中对软骨破坏的相对贡献尚未完全解决。这篇综述表明，ADAMTS-4/ADAMTS-5 均参与了 OA 患者的聚集蛋白聚糖降解，有望为 OA 的治疗干预列出正在关注的合理策略。
