Huang K, Wu L D
Department of Orthopaedics, Second Hospital of the Medical College, Zhejiang University, Hangzhou, China.
J Int Med Res. 2008 Nov-Dec;36(6):1149-60. doi: 10.1177/147323000803600601.
Aggrecanase-mediated aggrecan degradation is a significant event in early-stage osteoarthritis (OA). Aggrecanases belonging to the 'A Disintegrin And Metalloproteinase with ThromboSpondin motifs' (ADAMTS) family of proteinases play a significant role in aggrecan depletion in osteoarthritic cartilage. There has been considerable interest in the possible role of these aggrecanases, especially ADAMTS-4 and ADAMTS-5, as therapeutic targets in OA. This article discusses recent data regarding ADAMTS-4 and ADAMTS-5 in OA, with emphasis on the relationship between aggrecanase and aggrecan degradation as well as the role of aggrecanase in OA.
Aggrecan酶介导的聚集蛋白聚糖降解是早期骨关节炎（OA）中的一个重要事件。属于“具有血小板反应蛋白基序的解整合素和金属蛋白酶”（ADAMTS）蛋白酶家族的Aggrecan酶在骨关节炎软骨中聚集蛋白聚糖的消耗中起重要作用。这些Aggrecan酶，尤其是ADAMTS-4和ADAMTS-5，作为OA的治疗靶点可能发挥的作用引起了人们相当大的兴趣。本文讨论了关于OA中ADAMTS-4和ADAMTS-5的最新数据，重点是Aggrecan酶与聚集蛋白聚糖降解之间的关系以及Aggrecan酶在OA中的作用。
