Yang Kai, Zhang Yumin, Zhang Naili, Xu Weijun, Li Baoxing
China Institute for Radiation Protection, Taiyuan Shanxi, 030006, P.R.China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2013 Sep;27(9):1138-43.
To review the recent progress of the small intestinal submucosa (SIS) in application research of tissue repair and reconstruction.
The domestic and international articles on the SIS were reviewed and summarized.
As a natural extracellular matrix, SIS has outstanding biological advantages, such as good mechanical property, tissue compatibility, and lower immunogenicity. SIS has been used to repair and reconstruct various types of tissue defects in animal models and clinical application, especially in the treatment of hernia, urinary system disease, and refractory skin trauma. The development of the tissue engineering technology expands the field of SIS repair and reconstruction and promotes the intensive study of SIS. However, the long-term effect of SIS in tissue repair and reconstruction still remains to be further observation, while the cell/SIS material construction by tissue engineering technology also needs more studies.
SIS has a widely promising application future in the tissue repair and reconstruction.
综述小肠黏膜下层（SIS）在组织修复与重建应用研究中的最新进展。
对国内外有关SIS的文章进行回顾与总结。
作为一种天然的细胞外基质，SIS具有出色的生物学优势，如良好的力学性能、组织相容性和较低的免疫原性。SIS已被用于动物模型和临床应用中修复和重建各种类型的组织缺损，尤其是在治疗疝气、泌尿系统疾病和难治性皮肤创伤方面。组织工程技术的发展拓宽了SIS修复与重建的领域，并促进了对SIS的深入研究。然而，SIS在组织修复与重建中的长期效果仍有待进一步观察，而通过组织工程技术构建的细胞/SIS材料也需要更多研究。
SIS在组织修复与重建方面具有广阔的应用前景。
