从川芎中分离得到两种具有丁酰胆碱酯酶抑制活性的新型苯酞类化合物。
Two new phthalides with BuChE inhibitory activity from Ligusticum chuanxiong.
作者信息
Huang Jian, Lu Xiao-Qing, Lu Jin, Li Guo-Yu, Wang Hang-Yu, Li Li-Hong, Lin Rui-Chao, Wang Jin-Hui
机构信息
a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang , 110016 , China.
出版信息
J Asian Nat Prod Res. 2013;15(12):1237-42. doi: 10.1080/10286020.2013.825610. Epub 2013 Nov 27.
Two new phthalides, chuanxiongdiolides A and B, were isolated from the roots of Ligusticum chuanxiong Hort. Their structures were established by UV, IR, 1D (¹H, ¹³C) and 2D (HSQC, ¹H-¹H COSY, HMBC, NOESY) NMR, and HR-ESI-MS methods, and their absolute configurations were assigned via circular dichroism exciton chirality. The two compounds showed different degrees of inhibitory effects against butyrylcholine esterase.
从川芎的根部分离出两种新的苯酞类化合物，即川芎二醇内酯A和B。通过紫外光谱（UV）、红外光谱（IR）、一维核磁共振（¹H、¹³C）以及二维核磁共振（HSQC、¹H-¹H COSY、HMBC、NOESY）和高分辨电喷雾电离质谱（HR-ESI-MS）方法确定了它们的结构，并通过圆二色激子手性确定了它们的绝对构型。这两种化合物对丁酰胆碱酯酶表现出不同程度的抑制作用。
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