Pritchard D I, Behnke J M, Carr A, Wells C
Parasite Immunol. 1986 Jul;8(4):359-67. doi: 10.1111/j.1365-3024.1986.tb00852.x.
The surface antigens of adult Necator americanus were recognized by post-infection hamster sera and resolved at molecular weight 93,000, 67,000, 46,000, 43,000, 32,000 and 25,000. L4 larvae in contrast had one major surface antigen, resolving at 93,000. These antigens were also recognized by a range of human sera, although on a differential basis. This suggests that the human sera tion. However, the results do indicate that the hamster model might be of immunological relevance to the human disease state, in that infected hamster recognized the full cuticular antigen spectrum of adult Necator. This, at least, gives the experimenter a convenient reference point from which to conduct further experiments incorporating parameters such as re-infection, anthelmintic treatment and genetic variability to study the effect of these modifications on the serological response.
感染后仓鼠血清可识别美洲板口线虫成虫的表面抗原，这些抗原在分子量93,000、67,000、46,000、43,000、32,000和25,000处出现条带。相比之下，L4幼虫只有一种主要表面抗原，在93,000处出现条带。尽管存在差异，但这些抗原也能被一系列人血清识别。这表明人血清……然而，结果确实表明仓鼠模型在免疫学上可能与人类疾病状态相关，因为感染的仓鼠能够识别美洲板口线虫成虫完整的表皮抗原谱。至少，这为实验者提供了一个方便的参考点，以便在此基础上进行进一步实验，纳入再次感染、驱虫治疗和基因变异性等参数，来研究这些改变对血清学反应的影响。
