Department of Diagnosis and Biofunctional Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea; Department of Diagnosis and Biofunctional Medicine, Kyung Hee University Hospital at Gangdong, no. 149 Sangil-Dong Gangdong-Gu, Seoul 134-727, Republic of Korea.
Complement Ther Med. 2013 Dec;21(6):633-40. doi: 10.1016/j.ctim.2013.08.019. Epub 2013 Sep 1.
The present study was conducted to develop a valid and reliable Blood stasis questionnaire (BSQ), to define its optimum cut-off score, and to examine whether the BSQ score affected cardiovascular autonomic function.
Three hundred and thirty-eight outpatients (group A) and 61 inpatients (group B) were asked to complete the BSQ. In addition to the BSQ, heart rate variability parameters were recorded for group A. We estimated the internal consistency and construct validity for the BSQ data from group A. Three clinicians determined whether 61 inpatients (group B) exhibited blood stasis (BS), and we defined the optimum cut-off point for the BSQ using the clinicians' diagnoses and BSQ scores for group B. Finally, the differences in the HRV parameters between the BS and non-BS groups (group A) were examined.
The 12-item BSQ exhibited a satisfactory internal consistency (α=0.813). In the test of construct validity, a total of three factors (pain-lump, dark blue signs, and trauma) were extracted (total percentage of variance=54.8%). ROC curve analyses showed that the BSQ had a high discriminative ability for BS (AUC=0.948, 95% confidence interval 0.895-1.001). The optimum cut-off score for the BSQ was defined as three points. SDNN, TP, LF, and HF were lower in the BS group than in the non-BS group, indicating that the BS pattern partially caused a decrease in sympathetic and parasympathetic activities.
Our results suggest that the BSQ is a valid and reliable instrument for evaluating BS and BS may partially cause a decrease in cardiovascular autonomic function.
本研究旨在开发一种有效的、可靠的血瘀证问卷（BSQ），确定其最佳截断值，并探讨 BSQ 评分是否影响心血管自主神经功能。
338 名门诊患者（A 组）和 61 名住院患者（B 组）被要求完成 BSQ。除了 BSQ，A 组还记录了心率变异性参数。我们从 A 组估计了 BSQ 数据的内部一致性和结构有效性。三位临床医生判断 61 名住院患者（B 组）是否存在血瘀（BS），并使用临床医生的诊断和 B 组的 BSQ 评分来确定 BSQ 的最佳截断值。最后，检查了 BS 组和非 BS 组（A 组）的 HRV 参数差异。
12 项 BSQ 具有良好的内部一致性（α=0.813）。在结构有效性检验中，共提取了三个因子（疼痛肿块、暗蓝色征象和创伤）（总方差百分比=54.8%）。ROC 曲线分析表明，BSQ 对 BS 具有较高的鉴别能力（AUC=0.948，95%置信区间 0.895-1.001）。BSQ 的最佳截断值定义为 3 分。BS 组的 SDNN、TP、LF 和 HF 均低于非 BS 组，表明 BS 模式部分导致交感和副交感活动减少。
我们的结果表明，BSQ 是一种有效可靠的评估 BS 的工具，BS 可能部分导致心血管自主神经功能下降。
