Matsunaga Shigeki, Shibasaki Masakatsu
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, Japan.
Chem Commun (Camb). 2014 Feb 4;50(9):1044-57. doi: 10.1039/c3cc47587e.
Cooperative catalysis has proven to be a powerful strategy for realizing high reactivity and selectivity in asymmetric transformations. A variety of cooperative asymmetric catalysts have been developed over the last two decades. In this feature article, recent advances from our research on cooperative asymmetric catalysis, focusing on dinuclear Schiff base catalysis, are described. Design of dinuclear Schiff base catalysts and their applications in several asymmetric C-C and C-N bond-forming reactions under simple proton transfer conditions with perfect atom-economy are discussed in detail.
协同催化已被证明是在不对称转化中实现高反应活性和选择性的有力策略。在过去二十年中，已开发出多种协同不对称催化剂。在这篇专题文章中，描述了我们在协同不对称催化研究方面的最新进展，重点是双核席夫碱催化。详细讨论了双核席夫碱催化剂的设计及其在简单质子转移条件下、具有完美原子经济性的几种不对称碳-碳和碳-氮键形成反应中的应用。
