头颈部癌症起始细胞及其治疗的探索。
A quest for initiating cells of head and neck cancer and their treatment.
机构信息
Department of Otolaryngology and Head and Neck Surgery Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany.
出版信息
Cancers (Basel). 2010 Jul 27;2(3):1528-54. doi: 10.3390/cancers2031528.
The biology of head and neck squamous cell carcinomas (HNSCC) and other cancers have been related to cancer stem-like cells (CSC). Specific markers, which vary considerably depending on tumor type or tissue of origin, characterize CSC. CSC are cancer initiating, sustaining and mostly quiescent. Compared to bulk tumors, CSC are less sensitive to chemo- and radiotherapy and may have low immunogenicity. Therapeutic targeting of CSC may improve clinical outcome. HNSCC has two main etiologies: human papillomavirus, a virus infecting epithelial stem cells, and tobacco and alcohol abuse. Here, current knowledge of HNSCC-CSC biology is reviewed and parallels to CSC of other origin are drawn where necessary for a comprehensive picture.
头颈部鳞状细胞癌（HNSCC）和其他癌症的生物学特性与癌症干细胞样细胞（CSC）有关。CSC 的特征是具有特定的标记物，这些标记物因肿瘤类型或起源组织而异，差异很大。CSC 是癌症的起始、维持和主要静止细胞。与大量肿瘤相比，CSC 对化疗和放疗的敏感性较低，可能免疫原性较低。针对 CSC 的治疗性靶向可能会改善临床结果。HNSCC 有两种主要病因：人乳头瘤病毒，一种感染上皮干细胞的病毒，以及烟草和酒精滥用。在这里，我们综述了 HNSCC-CSC 生物学的现有知识，并在必要时与其他来源的 CSC 进行了比较，以全面了解这些内容。
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