Department of Systematic Pathology, Division of Dermatology, University of Naples Federico II, Naples, Italy.
Cancers (Basel). 2010 Nov 24;2(4):1980-9. doi: 10.3390/cancers2041980.
The incidence rate of melanoma and non-melanoma skin cancer entities is dramatically increasing worldwide. Exposure to UVB radiation is known to induce basal and squamous cell skin cancer in a dose-dependent way and the depletion of stratospheric ozone has implications for increases in biologically damaging solar UVB radiation reaching the earth's surface. In humans, arsenic is known to cause cancer of the skin, as well as cancer of the lung, bladder, liver, and kidney. Exposure to high levels of arsenic in drinking water has been recognized in some regions of the world. SCC and BCC (squamous and basal cell carcinoma) have been reported to be associated with ingestion of arsenic alone or in combination with other risk factors. The impact of changes in ambient temperature will influence people's behavior and the time they spend outdoors. Higher temperatures accompanying climate change may lead, among many other effects, to increasing incidence of skin cancer.
黑色素瘤和非黑色素瘤皮肤癌的发病率在全球范围内呈显著上升趋势。已知紫外线 B 辐射的照射会以剂量依赖的方式诱导基底细胞和鳞状细胞皮肤癌，而平流层臭氧的消耗会导致到达地球表面的生物破坏性太阳紫外线 B 辐射增加。在人类中，砷已知会导致皮肤癌以及肺癌、膀胱癌、肝癌和肾癌。在世界上的一些地区，人们已经认识到饮用水中高水平的砷会导致这些疾病。据报道，SCC 和 BCC（鳞状细胞癌和基底细胞癌）与单独摄入砷或与其他危险因素联合摄入砷有关。环境温度变化的影响将影响人们的行为和户外活动时间。气候变化带来的更高温度可能会导致皮肤癌发病率上升，这只是其中的一个影响。
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