Long G G, Scheidt A B, Everson R J, Oehme F W
Vet Hum Toxicol. 1986 Aug;28(4):297-9.
An aerosol preparation containing 2.5% chlorpyrifos was applied to the tail and umbilicus of newborn pigs. Mortality was 7/7 pigs treated 0-3 hr after birth, 3/5 pigs treated at 24-30 hr, and 0/3 pigs treated 30-36 hr after birth. Clinical signs consistent with organophosphate (OP) toxicosis were demonstrated by pigs that subsequently died or were euthanatized in extremis. Blood and brain cholinesterase (ChE) activities were depressed in affected pigs compared to controls. Only 1/3 pigs treated 30-36 hr after birth had a diagnostically significant depression in blood ChE. These results indicate that piglets one day or less of age are susceptible to OP toxicosis by cutaneous absorption of chlorpyrifos.
将含有2.5%毒死蜱的气雾剂制剂涂抹于新生仔猪的尾巴和脐部。出生后0 - 3小时接受治疗的7头仔猪全部死亡，出生后24 - 30小时接受治疗的5头仔猪中有3头死亡，出生后30 - 36小时接受治疗的3头仔猪全部存活。随后死亡或因极度痛苦而实施安乐死的仔猪表现出与有机磷（OP）中毒相符的临床症状。与对照组相比，患病仔猪的血液和脑胆碱酯酶（ChE）活性降低。出生后30 - 36小时接受治疗的仔猪中，只有1/3的血液ChE出现具有诊断意义的降低。这些结果表明，1日龄及以下的仔猪通过皮肤吸收毒死蜱易发生OP中毒。
