Cook James L, Kuroki Keiichi, Bozynski Chantelle C, Stoker Aaron M, Pfeiffer Ferris M, Cook Cristi R
Comparative Orthopaedic Laboratory and Missouri Orthopaedic Institute, University of Missouri, Columbia, Missouri.
J Knee Surg. 2014 Aug;27(4):295-302. doi: 10.1055/s-0033-1361951. Epub 2013 Nov 26.
This translational animal model study was designed to assess function, bone ingrowth and integration, and joint pathology associated with two different synthetic, bilayered osteochondral implants over a 3-month period after implantation into the femoral condyles of dogs. SynACart-Titanium (n = 6) and SynACart-PEEK (n = 6) (Arthrex, Naples, FL, and Sites Medical, Columbia City, IN) implants were press-fit into the lateral or medial femoral condyle (alternating location) of purpose-bred adult research dogs. Dogs were humanely euthanized 3 months after surgery and the operated knees were assessed radiographically, arthroscopically, grossly, and histologically. Based on all assessments, both types of implants were well tolerated and safe with no evidence for infection, migration, or rejection. Half of the SynACart-PEEK implants showed radiographic and histologic evidence of poor incorporation with all of these being in the lateral femoral condyle. SynACart-Titanium implants were considered effective in terms of integration into bone, lack of damage to surrounding and apposing articular cartilage, and maintenance of implant integrity and architecture for the duration of the study.
本转化动物模型研究旨在评估两种不同的合成双层骨软骨植入物在植入犬股骨髁后3个月内的功能、骨长入与整合情况以及关节病理学表现。将SynACart-钛合金（n = 6）和SynACart-聚醚醚酮（n = 6）（分别来自佛罗里达州那不勒斯的Arthrex公司以及印第安纳州哥伦比亚市的Sites Medical公司）植入物压配到专门培育的成年实验犬的外侧或内侧股骨髁（交替位置）。术后3个月对犬实施安乐死，并对手术膝关节进行放射学、关节镜、大体和组织学评估。基于所有评估，两种类型的植入物耐受性良好且安全，无感染、移位或排斥迹象。一半的SynACart-聚醚醚酮植入物显示出影像学和组织学证据表明其整合不佳，所有这些情况均发生在外侧股骨髁。在研究期间，SynACart-钛合金植入物在与骨的整合、对周围和相邻关节软骨无损伤以及维持植入物完整性和结构方面被认为是有效的。
