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慢性精神分裂症患者侧脑室大小的相关因素,II:生物学指标

Correlates of lateral ventricular size in chronic schizophrenia, II: biological measures.

作者信息

Losonczy M F, Song I S, Mohs R C, Mathé A A, Davidson M, Davis B M, Davis K L

出版信息

Am J Psychiatry. 1986 Sep;143(9):1113-8. doi: 10.1176/ajp.143.9.1113.

DOI:10.1176/ajp.143.9.1113
PMID:2428259
Abstract

CSF homovanillic acid levels showed a significant negative correlation with ventricle-brain ratios (VBRs) in a group of drug-free chronic schizophrenic male veterans, while CSF 5-hydroxyindoleacetic acid levels showed a similar, nearly significant trend. The response of plasma human growth hormone to 0.75 mg of apomorphine also demonstrated a significant negative correlation with VBR in this group, but other measures of central neurotransmitter activity were unrelated to ventricular size.

摘要

在一组未使用药物的慢性精神分裂症男性退伍军人中,脑脊液高香草酸水平与脑室-脑比率(VBRs)呈显著负相关,而脑脊液5-羟吲哚乙酸水平呈现出类似的、近乎显著的趋势。该组中,血浆人生长激素对0.75毫克阿扑吗啡的反应也与VBR呈显著负相关,但其他中枢神经递质活性指标与脑室大小无关。

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