核因子κB、细胞间黏附分子1和血管细胞黏附分子1在风湿性心脏病伴心房颤动中的表达
Expression of NFkappaB, ICAM1, and VCAM1 in rheumatic heart disease with atrial fibrillation.
作者信息
Chen Li-Ping, Liu Hui, Huang Yuan, Zhang Xiang-Yan, Alexander Riley E, Cheng Liang
机构信息
Department of Cardiology, Lishui City Hospital of Chinese Medicine, Lishui, China.
出版信息
Anal Quant Cytopathol Histpathol. 2013 Oct;35(5):249-52.
OBJECTIVE
To examine the expression of nuclear factor kappaB (NFkappaB), intercellular adhesion molecule 1 (ICAM1), and vascular cell adhesion molecule 1 (VCAM1) levels in rheumatic heart disease patients who suffer from atrial fibrillation and those who do not.
STUDY DESIGN
Twenty-six patients with rheumatic heart disease were enrolled. Ten patients had no history of atrial fibrillation and 16 had atrial fibrillation. Atrial tissue was obtained from the right atrial appendage during heart surgery. The expression levels of NFkappaB, ICAM1, and VCAM1 were examined with immunohistochemical staining.
RESULTS
Myocardial inflammation and fibrosis were both increased in patients with atrial fibrillation. The levels of NFkappaB, ICAM1, and VCAM1 were significantly elevated in patients with atrial fibrillation as compared with the control group (all p < 0.05).
CONCLUSION
Overexpression of NFkappaB, ICAM1, and VCAM1 may be involved in the development and maintenance of atrial fibrillation in patients with rheumatic heart disease.
目的
检测患有心房颤动和未患心房颤动的风湿性心脏病患者中核因子κB（NFκB）、细胞间黏附分子1（ICAM1）和血管细胞黏附分子1（VCAM1）的表达水平。
研究设计
招募了26例风湿性心脏病患者。其中10例无房颤病史，16例有房颤病史。在心脏手术期间从右心耳获取心房组织。采用免疫组织化学染色检测NFκB、ICAM1和VCAM1的表达水平。
结果
房颤患者的心肌炎症和纤维化均增加。与对照组相比，房颤患者的NFκB、ICAM1和VCAM1水平显著升高（均p<0.05）。
结论
NFκB、ICAM1和VCAM1的过表达可能参与风湿性心脏病患者心房颤动的发生和维持。
Zotero 插件