Soydinc H E, Evsen M S, Sak M E, Ozler A, Turgut A, Gul T
Department of Obstetric and Gynecology, Dicle University School ofMedicine, Diyarbakir, Turkey.
Clin Exp Obstet Gynecol. 2013;40(3):429-32.
Blood cells play a major role in homeostasis and inflammation. Primary dysmenorrhea (PD) involves the production of prostaglandins and leukotrienes, which cause inflammation in uterine tissue. Aim of this study was to investigate whether there is a relation between complete blood count parameters and PD during the menstrual cycle.
The study included 41 cases diagnosed as primary dysmenorrhea (mean age, 23.02 +/- 3.43 years) and 40 individuals who control subject (mean age, 23.76 +/- 3.13 years). Hematologic parameters were measured on menstrual phase (day 1-4), follicular phase (day 9-12), and luteal phase (day 21-23) during menstrual cycle.
There were no statistically differences between hematological parameters of two groups except for mean platelet volume (MPV). MPV of PD and control groups at each phase of menstrual cycle were 7.71 vs 8.61 (p = 0.01); 7.66 vs 8.56 (p = 0.005); 7.75 vs 8.53 (p = 0.01), respectively.
PD is associated with decreased MPV and platelets may be involved in the inflammatory process of PD.
血细胞在体内平衡和炎症中起主要作用。原发性痛经（PD）涉及前列腺素和白三烯的产生，这些物质会导致子宫组织发炎。本研究的目的是调查月经周期中全血细胞计数参数与PD之间是否存在关联。
该研究纳入了41例被诊断为原发性痛经的患者（平均年龄23.02±3.43岁）和40例对照个体（平均年龄23.76±3.13岁）。在月经周期的月经期（第1 - 4天）、卵泡期（第9 - 12天）和黄体期（第21 - 23天）测量血液学参数。
除平均血小板体积（MPV）外，两组的血液学参数无统计学差异。PD组和对照组在月经周期各阶段的MPV分别为7.71对8.61（p = 0.01）；7.66对8.56（p = 0.005）；7.75对8.53（p = 0.01）。
PD与MPV降低有关，血小板可能参与了PD的炎症过程。
