Department of Neurosurgery & Scottish Photodynamic Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom.
Photodiagnosis Photodyn Ther. 2013 Dec;10(4):362-7. doi: 10.1016/j.pdpdt.2013.03.007. Epub 2013 Apr 29.
Oral 5 aminolevulinic acid (5-ALA) is used to assist surgical resection of malignant tumours in the brain and other locations. Hypotension and alteration of liver functions have been reported as potential adverse effects. This study was designed to assess the incidence and contributing factors that cause 5-ALA induced side effects in a cohort of 90 patients. Hypotension occurred in 11% of patients irrespective of 5-ALA dose. The only contributing factor was the presence of cardiovascular disease and antihypertensive drug therapy with an odd ratio of 17.7. Liver function were disturbed in 2% in patients who received 20mg or less/kg body weight compared to 4% in those who received a dose of >20mg/kg 5-ALA. The liver dysfunction was minor and was not clinically significant. We concluded that 5-ALA induced side effects were minimal and hypotension more likely to occur in patients receiving antihypertensive drug therapy.
口服 5-氨基酮戊酸（5-ALA）用于辅助脑部和其他部位的恶性肿瘤的手术切除。据报道，低血压和肝功能改变是其潜在的不良反应。本研究旨在评估 90 例患者中 5-ALA 诱导的副作用的发生率和相关因素。无论 5-ALA 剂量如何，低血压在 11%的患者中发生。唯一的相关因素是心血管疾病的存在和使用抗高血压药物治疗，其比值比为 17.7。与接受 20mg/kg 以下 5-ALA 剂量的患者相比，接受 20mg/kg 或以上 5-ALA 剂量的患者中，有 2%的患者肝功能受到干扰，而有 4%的患者肝功能受到干扰。肝功能障碍轻微，无临床意义。我们得出结论，5-ALA 诱导的副作用很小，接受抗高血压药物治疗的患者更有可能发生低血压。
