Elliott P J, Iversen S D
Brain Res. 1986 Aug 27;381(1):68-76. doi: 10.1016/0006-8993(86)90691-8.
Substance P (SP) and related tachykinins administered either intracerebroventricularly or directly into the ventral tegmental area of the mesencephalon of rat brain caused increased locomotor activity, grooming behaviour and wet dog shakes. Kassinin, eledoisin, neurokinin A and DiMe-C7, agonists with some selectivity for the SP-E-receptor elicited the greatest locomotor activity and wet dog shake responses, whereas SP and physalaemin which are more selective for the SP-P-receptor were most effective in eliciting the grooming response.
将P物质（SP）及相关速激肽经脑室注射或直接注入大鼠脑内中脑腹侧被盖区，会导致其运动活性增加、梳理行为及湿狗样抖动。对SP-E受体具有一定选择性的激动剂——蛙皮素、伊列多因、神经激肽A和二甲基- C7，引发的运动活性和湿狗样抖动反应最为强烈，而对SP-P受体更具选择性的SP和雨蛙肽在引发梳理反应方面最为有效。
