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Substance P analog, DiMe-C7: evidence for stability in rat brain and prolonged central actions.

作者信息

Eison A S, Iversen S D, Sandberg B E, Watson S P, Hanley M R, Iversen L L

出版信息

Science. 1982 Jan 8;215(4529):188-90. doi: 10.1126/science.6171884.

DOI:10.1126/science.6171884
PMID:6171884
Abstract

A metabolically protected analog of substance P, [pGlu5-MePhe8-MeGly9]SP(5-11) (DiMe-C7), was approximately equipotent with substance P in causing increased locomotor activity after microinfusion into the ventral tegmental area of rat brain, but the effects of DiMe-C7 on behavior were considerably prolonged. There was little metabolic degradation of tritiated DiMe-C7 for up to 1 hour after infusion, whereas tritiated substance P was completely degraded within 10 minutes.

摘要

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