Stanley M W, Kiang D T, Sibley R K
Cancer. 1986 Nov 1;58(9):2046-51. doi: 10.1002/1097-0142(19861101)58:9<2046::aid-cncr2820580915>3.0.co;2-y.
Previous reports have shown binding of peanut agglutinin (PNA) by immunoperoxidase techniques in normal, benign proliferative, and malignant breast epithelia. Correlation of binding with maturity, secretory activity, hormonal milieu, and tissue hormone receptor content has been described. To investigate the relationship between PNA staining by the avidin-biotin complex technique and estrogen receptor (ER) content, 79 breast tumors of different types and known tissue ER content were studied. Thirty-eight of 50 ER-positive cases were PNA-positive. Twenty of 29 ER-negative cases were PNA-positive. Statistical analysis shows the two factors to be independent (0.5 less than P less than 0.9). The literature on blood group antigens in breast carcinoma and histochemical applications of PNA is reviewed.
先前的报告显示，通过免疫过氧化物酶技术可在正常、良性增生性和恶性乳腺上皮中检测到花生凝集素（PNA）的结合。已描述了其结合与成熟度、分泌活性、激素环境及组织激素受体含量之间的相关性。为了研究抗生物素蛋白-生物素复合物技术检测的PNA染色与雌激素受体（ER）含量之间的关系，我们对79例不同类型且已知组织ER含量的乳腺肿瘤进行了研究。50例ER阳性病例中有38例PNA阳性。29例ER阴性病例中有20例PNA阳性。统计分析表明这两个因素相互独立（0.5＜P＜0.9）。本文对乳腺癌血型抗原及PNA组织化学应用的文献进行了综述。
