气道中的瞬时受体电位（TRP）通道：在气道疾病中的作用
Transient receptor potential (TRP) channels in the airway: role in airway disease.
作者信息
Grace M S, Baxter M, Dubuis E, Birrell M A, Belvisi M G
机构信息
Respiratory Pharmacology, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK.
出版信息
Br J Pharmacol. 2014 May;171(10):2593-607. doi: 10.1111/bph.12538.
Abstract
Over the last few decades, there has been an explosion of scientific publications reporting the many and varied roles of transient receptor potential (TRP) ion channels in physiological and pathological systems throughout the body. The aim of this review is to summarize the existing literature on the role of TRP channels in the lungs and discuss what is known about their function under normal and diseased conditions. The review will focus mainly on the pathogenesis and symptoms of asthma and chronic obstructive pulmonary disease and the role of four members of the TRP family: TRPA1, TRPV1, TRPV4 and TRPM8. We hope that the article will help the reader understand the role of TRP channels in the normal airway and how their function may be changed in the context of respiratory disease.
摘要
在过去几十年中，科学出版物激增，报道了瞬时受体电位（TRP）离子通道在全身生理和病理系统中的多种不同作用。本综述的目的是总结关于TRP通道在肺部作用的现有文献，并讨论在正常和患病条件下对其功能的了解。该综述将主要关注哮喘和慢性阻塞性肺疾病的发病机制和症状，以及TRP家族四个成员的作用：TRPA1、TRPV1、TRPV4和TRPM8。我们希望这篇文章能帮助读者了解TRP通道在正常气道中的作用，以及它们在呼吸系统疾病背景下的功能可能如何改变。
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