Sardi J E, di Paola G R, Cachau A, Ortiz O C, Sananes C, Giaroli A, Martins D, Peluffo M
Gynecol Oncol. 1986 Oct;25(2):139-49. doi: 10.1016/0090-8258(86)90095-8.
Thirty-three patients with locally advanced carcinoma of the cervix were treated with chemotherapy as first line treatment. Great emphasis was applied to document, in the most objective manner, the tumor size response. The first 8 patients received a conventional scheme composed of vincristine, bleomycin and cis-platinum (VBP) at 21-day intervals. The results were not as satisfactory as expected. In the other 25 patients a more aggressive VBP scheme was used, at 10-day intervals. Surprisingly satisfactory results and tolerance were observed. In many instances verified tumor reduction allowed surgical radical treatment in prechemotherapy inoperable cases.
33例局部晚期宫颈癌患者接受了化疗作为一线治疗。我们极为重视以最客观的方式记录肿瘤大小的反应。前8例患者接受了由长春新碱、博来霉素和顺铂（VBP）组成的传统方案，每21天给药一次。结果并不像预期的那样令人满意。在另外25例患者中，采用了更积极的VBP方案，每10天给药一次。观察到了令人惊讶的满意结果和耐受性。在许多情况下，经证实的肿瘤缩小使得化疗前无法进行手术根治的病例能够接受手术根治治疗。
