Syrbe G, Jütte A, Wittwer E, Deufrains A
Folia Haematol Int Mag Klin Morphol Blutforsch. 1986;113(3):317-28.
In 198 diabetic patients of type I and type II and in 111 healthy persons of a control group the activity of fibrinolysis was investigated before and after a venous occlusion test of ten minutes. Spontaneous fibrinolysis was significantly diminished in diabetics of both types in comparison to the control group. A relationship to the degree of seriousness of retinopathy could not be identified in type I. The activity of fibrinolysis decreased in all test persons in old age. In diabetics patients of type II as well as in that age group being more than 56 years old there were smaller activities of fibrinolysis at higher stages of retinopathy. A negative linear correlation of this spontaneous activity of fibrinolysis could be found for the duration of the disease as well as for age. Different forms of diabetic therapy and the sex allowed no influence of the activity of fibrinolysis to be recognized. An increase of the activity of fibrinolysis after congestion could be established in diabetics as well as in the control group. After venous congestion the fibrinolytic activity showed no differences any longer in diabetics and in the control group, with age, duration of the disease and form of therapy being taken into consideration. Before and after venous congestion a negative linear correlation could be revealed between the activity of fibrinolysis and the height of blood sugar level. Therefore, the real blood sugar concentration should be taken into account in evaluating the fibrinolytic activity.
对198例I型和II型糖尿病患者以及111例健康对照组人员在进行10分钟静脉阻塞试验前后的纤溶活性进行了研究。与对照组相比，两种类型的糖尿病患者的自发纤溶活性均显著降低。在I型糖尿病中未发现与视网膜病变严重程度的关系。所有受试人员的纤溶活性随年龄增长而降低。在II型糖尿病患者以及年龄超过56岁的人群中，在视网膜病变较高阶段纤溶活性较低。纤溶的这种自发活性与病程以及年龄呈负线性相关。不同的糖尿病治疗方式和性别对纤溶活性均无影响。糖尿病患者和对照组在充血后纤溶活性均会增加。在考虑年龄、病程和治疗方式的情况下，糖尿病患者和对照组在静脉充血后的纤溶活性不再有差异。在静脉充血前后，纤溶活性与血糖水平高度之间呈负线性相关。因此，在评估纤溶活性时应考虑实际血糖浓度。
