Syrbe G, Schröder H, Keil E, Jütte A
Klinik für Innere Medizin, Arbeitsgruppe EDV, Friedrich-Schiller-Universität, Jena.
Folia Haematol Int Mag Klin Morphol Blutforsch. 1990;117(5):717-23.
In 309 patients investigations were made into the functions of blood coagulation with special consideration of numerous metabolic criteria. They referred to 111 healthy control persons and 198 patients with diabetes mellitus, 67 of them being of type I and 131 of type II. From a variety of metabolic characteristics and haemostasis optimal criteria were determined by means of the statistical method of multivariance analysis, which enables a distinction to be made between diabetics of type I, type II and healthy persons. Among those 13 characteristics detected as optimal amount there were thrombin time, thrombin coagulase time as parameter of haemostasis both before and after venous congestion, reptilase time prior to venous congestion and fibrinogen concentration after it. Thus, these coagulation factors indicate a different behaviour in both types of diabetes and in healthy control persons.
对309例患者的凝血功能进行了研究，并特别考虑了众多代谢指标。研究对象包括111名健康对照者和198例糖尿病患者，其中67例为I型糖尿病患者，131例为II型糖尿病患者。通过多变量分析的统计方法，从各种代谢特征和止血指标中确定了最佳标准，该方法能够区分I型糖尿病患者、II型糖尿病患者和健康人。在检测到的13项最佳指标中，有凝血酶时间、静脉充血前后作为止血参数的凝血酶凝固酶时间、静脉充血前的蛇毒凝血酶时间和充血后的纤维蛋白原浓度。因此，这些凝血因子在两种类型的糖尿病患者和健康对照者中表现出不同的行为。
