Department of Systems Biology, Harvard Medical School, Boston, MA 02115; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115.
Mol Biol Cell. 2013 Dec;24(23):3585-7. doi: 10.1091/mbc.E13-03-0155.
The elaborate spatial organization of cells enhances, restricts, and regulates protein-protein interactions. However, the biological significance of this organization has been difficult to study without ways of directly perturbing it. We highlight synthetic biology tools for engineering novel cellular organization, describing how they have been, and can be, used to advance cell biology.
细胞的精细空间组织增强、限制和调节蛋白质-蛋白质相互作用。然而，如果没有直接干扰这种组织的方法，那么研究这种组织的生物学意义就很困难。我们重点介绍了用于工程新型细胞组织的合成生物学工具，并描述了它们已经并可以用于推进细胞生物学的研究。
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