University of Basel, Department of Chemistry, Klingelbergstr. 80, CH-4056 Basel, Switzerland.
FEBS Lett. 2012 Jul 16;586(15):2146-56. doi: 10.1016/j.febslet.2012.05.033. Epub 2012 Jun 12.
The topic synthetic biology appears still as an 'empty basket to be filled'. However, there is already plenty of claims and visions, as well as convincing research strategies about the theme of synthetic biology. First of all, synthetic biology seems to be about the engineering of biology - about bottom-up and top-down approaches, compromising complexity versus stability of artificial architectures, relevant in biology. Synthetic biology accounts for heterogeneous approaches towards minimal and even artificial life, the engineering of biochemical pathways on the organismic level, the modelling of molecular processes and finally, the combination of synthetic with nature-derived materials and architectural concepts, such as a cellular membrane. Still, synthetic biology is a discipline, which embraces interdisciplinary attempts in order to have a profound, scientific base to enable the re-design of nature and to compose architectures and processes with man-made matter. We like to give an overview about the developments in the field of synthetic biology, regarding polymer-based analogs of cellular membranes and what questions can be answered by applying synthetic polymer science towards the smallest unit in life, namely a cell.
这个主题的合成生物学似乎仍然是一个“有待充实的空篮子”。然而,关于合成生物学的主题已经有了大量的主张和设想,以及令人信服的研究策略。首先,合成生物学似乎是关于生物学的工程——关于自下而上和自上而下的方法,在生物学中权衡人工结构的复杂性与稳定性。合成生物学涉及到对最小甚至人工生命的异质方法、在机体水平上的生化途径的工程、分子过程的建模,以及最终将合成与天然衍生的材料和结构概念相结合,例如细胞膜。尽管如此,合成生物学是一门学科,它包含跨学科的尝试,以便为重新设计自然提供深刻的科学基础,并利用人造物质来构成结构和过程。我们想概述一下合成生物学领域的发展,涉及基于聚合物的细胞膜类似物,以及通过应用合成聚合物科学来回答生命中最小的单位——即细胞——的哪些问题。