Tang Yanwei, Zhao Yan, Wang Xungai, Lin Tong
Institute for Frontier Materials, Deakin University, Geelong, Victoria, 3216, Australia.
J Biomed Mater Res A. 2014 Nov;102(11):3803-12. doi: 10.1002/jbm.a.35050. Epub 2013 Dec 12.
Silica nanoparticles were applied onto the fiber surface of an interbonded three-dimensional polycaprolactone fibrous tissue scaffold by an electrostatic layer-by-layer self-assembly technique. The nanoparticle layer was found to improve the fiber wettability and surface roughness. Osteoblast cells were cultured on the fibrous scaffolds to evaluate the biological compatibility. The silica nanoparticle coated scaffold showed enhanced cell attachment, proliferation, and alkaline phosphatase activities. The overall results suggested that interbonded fibrous scaffold with silica nanoparticulate coating could be a promising scaffolding candidate for various applications in bone repair and regeneration.
通过静电逐层自组装技术将二氧化硅纳米颗粒应用于相互粘结的三维聚己内酯纤维组织支架的纤维表面。发现纳米颗粒层改善了纤维的润湿性和表面粗糙度。在纤维支架上培养成骨细胞以评估生物相容性。涂覆有二氧化硅纳米颗粒的支架显示出增强的细胞附着、增殖和碱性磷酸酶活性。总体结果表明，具有二氧化硅纳米颗粒涂层的相互粘结纤维支架可能是骨修复和再生各种应用中有前景的支架候选材料。
