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明矾催化在水介质中简单、高效且绿色地合成2-[3-氨基-5-甲基-5-(吡啶-3-基)-1,5-二氢-4H-1,2,4-三唑-4-基]丙酸衍生物。

Alum catalyzed simple, efficient, and green synthesis of 2-[3-amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic acid derivatives in aqueous media.

作者信息

Sachdeva Harshita, Dwivedi Diksha, Saroj Rekha

机构信息

Department of Chemistry, Faculty of Engineering and Technology, Mody Institute of Technology and Science, Lakshmangarh, Sikar, Rajasthan 332311, India.

出版信息

ScientificWorldJournal. 2013 Oct 29;2013:716389. doi: 10.1155/2013/716389. eCollection 2013.

DOI:10.1155/2013/716389
PMID:24288503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3830769/
Abstract

Alum (KAl(SO4)2 · 12H2O) is an inexpensive, efficient, and nontoxic catalyst used for the synthesis of 2-[3-amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic acid derivatives in aqueous media by the reaction of 3-acetyl pyridine (1), amino acids (2)/(6), and thiosemicarbazide (4) at 80 °C. This methodology offers significant improvements for the synthesis of products with regards to the yield of products, simplicity in operation, and green aspects by avoiding toxic catalysts which uphold the motto of green chemistry. Synthesized compounds have been characterized by FT-IR, (13)C NMR, and (1)HNMR spectroscopy.

摘要

明矾（KAl(SO₄)₂·12H₂O）是一种廉价、高效且无毒的催化剂，用于在水介质中，通过3-乙酰基吡啶（1）、氨基酸（2）/（6）和氨基硫脲（4）在80℃下反应合成2-[3-氨基-5-甲基-5-(吡啶-3-基)-1,5-二氢-4H-1,2,4-三唑-4-基]丙酸衍生物。该方法在产物产率、操作简便性以及绿色环保方面（通过避免使用有毒催化剂，秉持绿色化学理念）为产物的合成带来了显著改进。合成的化合物已通过傅里叶变换红外光谱（FT-IR）、碳-13核磁共振（¹³C NMR）和氢-1核磁共振（¹H NMR）光谱进行了表征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9176/3830769/c4bc95bbe45a/TSWJ2013-716389.sch.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9176/3830769/c4bc95bbe45a/TSWJ2013-716389.sch.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9176/3830769/c4bc95bbe45a/TSWJ2013-716389.sch.001.jpg

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