Khlebnikova N N, Krupina N A, Bogdanova N G, Zolotov N N
Laboratory of General Pathology of the Nervous System, Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences; Laboratory of Psychopharmacology, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Bull Exp Biol Med. 2013 Oct;155(6):711-4. doi: 10.1007/s10517-013-2233-y.
A noncompetitive synthetic inhibitor of prolyl endopeptidase benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine (1.0 mg/kg intraperitoneally for 2 weeks) prevented the increase in activity of prolyl endopeptidase in the frontal cortex, striatum, and hypothalamus and activation of dipeptidyl peptidase IV in the frontal cortex of rats with experimental dopamine deficiency-dependent depressive syndrome caused by administration of proneurotoxin MPTP (2 weeks). Our results suggest that the antidepressive effect of prolyl endopeptidase inhibitor is at least partly related to prevention of enzyme activation in the frontal cortex. The antistress effect of this substance can be associated with prevention of enzyme activation in the hypothalamus.
