Khlebnikova N N, Krupina N A, Kushnareva E Yu, Zolotov N N, Kryzhanovskii G N
Laboratory for General Pathology of Nervous System, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia.
Bull Exp Biol Med. 2012 Feb;152(4):409-12. doi: 10.1007/s10517-012-1540-z.
Activities of prolyl endopeptidase and dipeptidyl peptidase IV in the frontal cortex, hypothalamus, nucleus accumbens, striatum, and hippocampus were measured in rats with the experimental anxious-depressive syndrome induced by treatment with a dipeptidyl peptidase IV inhibitor during the early postnatal period (days 5-18). Prolyl endopeptidase activity was elevated in the frontal cortex, hypothalamus, and nucleus accumbens. Increased activity of dipeptidyl peptidase IV was observed in the hypothalamus and striatum. Norepinephrine/serotonin reuptake inhibitor, imipramine, and noncompetitive prolyl endopeptidase inhibitor, benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine, were shown to abolish depression-like behavior of animals in the forced swimming test. These compounds had a normalizing effect on activities of prolyl endopeptidase and dipeptidyl peptidase IV in brain structures of rats.
